Table 5.
Examples of genes upregulated in the aortas of mice exposed to angiotensin II which did not develop aneurysms. These genes are potentially protective against AAA.
| Gene symbol | Gene ID | Description | Fold increase cf AAA | P value | Fold increase cf saline | P value |
| Cald1† | 109624 | caldesmon 1 | 2.053388 | 0.000625 | 2.379 | 5.64E-06 |
| Acta2† | 11475 | actin, alpha 2, smooth muscle, aorta | 2.178649 | 0.0284 | 2.536 | 1.84E-06 |
| Sost† | 74499 | sclerostin | 2.659574 | 0.0118 | 2.167 | 9.01E-06 |
| Kcnmb1† | 16533 | potassium large conductance calcium-activated channel, subfamily M, beta member 1. | 2.004008 | 0.0129 | 2.262 | 7.45E-07 |
| Dstn† | 56431 | destrin | 2.169197 | 0.00498 | 2.242 | 6.70E-06 |
| Timp4† | 110595 | tissue inhibitor of metalloproteinase 4 | 2 | 1.99E-05 | ns | ns |
| Pdlim3† | 53318 | PDZ and LIM domain 3 | 2.12766 | 0.00386 | ns | ns |
| Rgs17† | 56533 | regulator of G-protein signaling 17 | 2.439024 | 0.00106 | ns | ns |
| Hspa1l | 15482 | heat shock protein 1-like | 2.020202 | 0.00844 | ns | ns |
| Gabra3 | 14396 | gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 3 | 2.028398 | 0.00482 | ns | ns |
| Btc† | 12223 | betacellulin, epidermal growth factor family member | 2.314815 | 0.0412 | ns | ns |
| Fbxo30 | 71865 | F-box protein 30 | 2.325581 | 0.000911 | ns | ns |
| Hspa1†a | 193740 | heat shock protein 1A | 2.262443 | 0.00944 | ns | ns |
| Mtap1b† | 17755 | microtubule-associated protein 1B | 2.252252 | 0.0363 | ns | ns |
| Xirp1 | 22437 | cardiomyopathy associated 1 | 2.155172 | 0.0165 | ns | ns |
| Klk10 | 69540 | Kallikrein 10 | 2.136752 | 7.42E-05 | ns | ns |
| Slc22a1† | 20517 | solute carrier family 22 (organic cation transporter), member 1 | 2.873563 | 0.000794 | ns | ns |
Shown are examples of genes which were significantly up-regulated (2-fold, uncorrected p value < 0.05 calculated with unpaired t-test) within the aortas of mice that received angiotensin II and did not develop AAAs by comparison to mice which developed AAAs. Also shown is comparison with findings from the aortas of saline control mice. Genes were selected from the full list of differentially expressed genes (shown in Additional File 9) based on their likely functional importance and previous association with human AAA. Genes highlighted with † have previously been identified as down-regulated within human AAA in a whole genome expression study [9]. Cf: compared to; ns: not significant.