Table 6.

Validation of genes up-regulated in AAA by real time PCR.

Gene symbol	Gene ID	Description; synonym	Relative expression in AAA	Relative expression in no AAA	Relative expression in saline control	P value AAA v no AAA	P value AAA v saline control
Ccl4†	20303	chemokine (C-C motif) ligand 4; MIP-1B	52.71 (19.80–133.40)	5.55 (4.87–9.91)	1.40 (0.84–2.49)	0.009	0.004
Ccl8†	20307	chemokine (C-C motif) ligand 8; MCP-2	8.84 (5.94–12.25)	1.66 (1.27–2.73)	0.84 (0.55–1.18)	0.009	0.004
Mmp2†	17390	matrix metalloproteinase 2	4.58 (3.80–11.00)	2.30 (1.50–3.17)	0.97 (0.81–1.06)	0.004	0.004
Il6†	16193	interleukin 6	70.87 (14.40–184.59)	9.49 (2.54–16.83)	0.46 (0.17–1.26)	0.030	0.004

Shown are median (inter-quartile range) of relative gene expression (compared to house-keeping gene) in whole aortas used in the micro-array studies removed from mice exposed to angiotensin II that developed AAAs (n = 5) or no AAA (n = 7) or saline controls (n = 6).