Table 2.

The distribution of immunoreactive POP protein (POP-IHC), POP coding mRNA, and POP enzyme activity in various studies

	Enzyme activity						mRNA		POP-IHC
Brain
References	Irazusta et al. 2002	Kato et al. 1980b	Agirregoitia et al. 2005	Irazusta et al. 2002	Fuse et al. 1990	Daly et al. 1985	GNF SymAtlas, Su et al. 2002	Bellemere et al. 2004	Myöhänen et al. 2007	Myöhänen et al. 2008b
Species	Human	Human	Sprague-Dawley rat	Sprague-Dawley rat	Wistar rat	Wistar rat	Human	Wistar rat	Human	Wistar rat
Cortex	+++	+++	+++	+++	+++	+++	++	++	+++	+++
Striatum	++	+	+++	+++			+	++	+++	+++
Cerebellum	+	+	+++	++			+	+++	+++	+++
Hippocampus	++			+++				++	+++	+++
Hypothalamus	++			++	++		++	+++		ND
Thalamus							++	++		++
Substantia nigra								+	+++	+++
Peripheral tissues
References	Goossens et al. 1996	Kato et al. 1980b	Agirregoitia et al. 2005	Myöhänen et al. 2008c	Fuse et al. 1990	Daly et al. 1985	GNF SymAtlas, Su et al. 2002		Myöhänen et al. 2008c
Species	Human	Human	Sprague-Dawley rat	NMRI mouse	Wistar rat	Wistar rat	Human		NMRI mouse
Lung	++		+	++	+	+++	+		++
Kidney	+++	+++	+	+	+++	+			+++
Spleen	++				+	+
Liver				+++	+++	+++	+		+
Urinary bladder	+			+					++
Testis		+++		+++	++		++		+++
Heart		+		++	+	+	+		+
Gut					+
Skeletal muscle						++
Cells
References	Goossens et al. 1996	Schulz et al. 2005	Mentlein et al. 1990	Koshiya et al. 1984			GNF SymAtlas, Su et al. 2002			Myöhänen et al. 2008b
Species	Human	Human	Wistar rat	Wistar rat			Human			Wistar rat
Neurons		+++	+++	+++						+++
Astrocytes		++	+++							ND
Oligodendrocytes		+	+
Lymphocytes	++						+++
Epithelial cells	+++

+++, high expression; ++, moderate expression; +, low expression; ND, not detectable; NMRI, Navy Medical Research Institution.