Table 3.
Subcellular localization of POP in tissues and cell lines
| Tissue/cell line | Cytoplasm | Cell membranes | Microtubulus | RER | Golgi apparatus | Mitochondria | Nucleus | Method | Reference |
|---|---|---|---|---|---|---|---|---|---|
| Rat brain | +++ | + | − | + | + | − | − | IHC-EM | Myöhänen et al. 2008b |
| Rabbit brain | +++ | + | Activity | Dresdner et al. 1982 | |||||
| Mouse brain | +++ | IFL | Rossner et al. 2005 | ||||||
| Human glioma cell line (LN-405) | +++ | ++ | IFL | Schulz et al. 2005 | |||||
| Neuroblastoma cell line (SH-SY5Y) | +++ | ++ | IFL | Schulz et al. 2005 | |||||
| Mouse peripheral tissues | ++ | +++ | IHC | Myöhänen et al. 2008c | |||||
| Cerebellar neurons (primary culture) | |||||||||
| Young | ++ | +++ | FLI/WB/Activity | Moreno-Baylach et al. 2008 | |||||
| Mature | ++ | + | 0 | FLI/WB/Activity | Moreno-Baylach et al. 2008 | ||||
| Aged | +++ | + | 0 | FLI/WB/Activity | Moreno-Baylach et al. 2008 | ||||
| Swiss 3T3 cell culture | ++ | ++ | IFL | Ishino et al. 1998 | |||||
| Sarcophaga peregrina (flesh fly) embryonic cells | + | +++ | IFL | Ohtsuki et al. 1994 | |||||
The densities of POP in cell structures: −, no POP; +, low density of POP; ++, moderate density of POP; +++, high density of POP. FLI, fluorescent POP-inhibitor; IFL, immunofluorescence; IHC, immunohistochemistry; IHC-EM, immuno-electronmicroscopy; RER, rough endoplasmic reticulum; WB, Western blotting.