Table 3.

Stratified hazard ratio (HR) estimates and 95% confidence intervals (CI) of associations between family history of breast cancer and all-cause mortality

Proband or tumor characteristic	First-degree relatives	Deaths (N)	HR* (95% CI)	pheterogeneity
Age at diagnosis <40 years	None	264	0.86 (0.58-1.27)
	≥1	29	p = 0.44
Age at diagnosis ≥40 years	None	314	0.84 (0.67-1.05)
	≥1	118	p = 0.13	0.92
No affected lymph nodes	None	156	1.08 (0.77-1.51)
	≥1	54	p = 0.65
1-3 affected lymph nodes	None	196	0.64 (0.44-0.93)
	≥1	34	p = 0.02
≥4 affected lymph nodes	None	144	1.03 (0.70-1.52)
	≥1	42	p = 0.87	0.20
Tumor size ≤20 mm	None	261	0.93 (0.71-1.21)
	≥1	79	p = 0.58
Tumor size >20 mm	None	260	0.77 (0.57-1.05)
	≥1	58	p = 0.10	0.41
Tumor grade 1	None	36	0.93 (0.47-1.85)
	≥1	14	p = 0.83
Tumor grade 2	None	182	0.69 (0.48-0.98)
	≥1	41	p = 0.04
Tumor grade 3	None	316	0.98 (0.75-1.27)
	≥1	79	p = 0.85	0.38
Ductal	None	489	0.85 (0.67-1.04)
	≥1	126	p = 0.12
Lobular	None	38	0.67 (0.30-1.51)
	≥1	9	p = 0.34
Other	None	23	0.90 (0.37-2.20)
	≥1	9	p = 0.82	0.34
Estrogen-receptor-negative	None	194	0.81 (0.57-1.15)
	≥1	43	p = 0.24
Estrogen-receptor-positive	None	313	0.95 (0.74-1.22)
	≥1	96	p = 0.69	0.34
Progesterone-receptor-negative	None	187	0.99 (0.72-1.38)
	≥1	54	p = 0.99
Progesterone-receptor-positive	None	318	0.84 (0.65-1.09)
	≥1	84	p = 0.19	0.59
Ontario	None	198	0.77 (0.57-1.03)
	≥1	57	p = 0.08
Northern California	None	122	0.84 (0.61-1.17)
	≥1	65	p = 0.30
Australia	None	258	0.87 (0.57-1.31)
	≥1	25	p = 0.49	0.82

^*Adjusted for age, Breast CFR center, race/ethnicity, number of affected lymph nodes, tumor size, tumor grade, histologic type, estrogen receptor status, and progesterone receptor status