Table 1.
1A: Expression of XIAP (% of cells positive) in normal control adult and pediatric whole blood samples, using the clone 2F1 antibody. 1B: Expression of XIAP (% of cells positive and geometric mean channel fluorescence (gMCF)) in normal control adult and pediatric whole blood samples using the clone 48 antibody.
| Control Group | CD3+/CD4+ XIAP + |
CD3+/CD8+ XIAP+ |
CD3−/CD56+ XIAP+ |
CD3−/CD19+ XIAP+ |
|---|---|---|---|---|
| 1A. Clone 2F1 | ||||
| Pediatric: ages 7 months to 18 years, n=56, 45% male |
65–97%# | 61–96% | 59–95% | 45–90% |
| Adult: ages 19 to 60 years, n=11 , 36% male |
77–98% | 75–100% | 60–100% | 48–92% |
| 1B. Clone 48 | ||||
| Pediatric: ages 1year to 18 years; n=22, 45% male |
93–99% gMCF* 13–41 |
92–100% gMCF 13–39 |
93–100% gMCF 14–39 |
87–98% gMCF 10–27 |
| Adult: ages 22 to 60 years, n=24, 29% male |
94–100% gMCF 23–50 |
94–100% gMCF 21–52 |
94–100% gMCF 20–50 |
91–98% gMCF 14–35 |
#
percent of cells positive for XIAP, range calculated as mean +/− 2 standard deviations
*
geometric mean channel fluorescence, range calculated as mean +/− 2 standard deviations