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. Author manuscript; available in PMC: 2010 Aug 1.
Published in final edited form as: Cell Cycle. 2009 Aug 22;8(16):2662–2663. doi: 10.4161/cc.8.16.9329

Fig. 1.

Fig. 1

SIRT6 deacetylates H3 K56Ac. (A) Hyperacetylation of H3 K56Ac in the absence of SIRT6. (Left panel) Hyperacetylation of H3 K56Ac in SIRT6-deficient MEFs. (Middle panel) Hyperacetylation of H3 K56Ac in SIRT6-deficient ES cells. (Right panel) Reconstitution of a SIRT6-deficient fibroblast cell line with catalytically active SIRT6 reduces H3 K56Ac levels. (B) Immunofluorescence analysis of SIRT6-deficient MEFs and littermate controls. (C) Hyperacetylation of H3 K56Ac in thymus (top panels) and brain (bottom panels) of a SIRT6-deficient mouse and littermate control. (D) Recombinant SIRT6 deacetylates H3 K56Ac in vitro.