Table 3.

PolyHeme clinical trials

Patient Population	Control Dosage	HBOC Dosage	Physiologic Effects	Treatment Effects
Surgical/Trauma Patients23	Allogeneic PRBC transfusion (n=23), PRN	(n=21), Up to 6Ua	None reported	Maintained total [Hb], but not RBC [Hb]*
Trauma Patients35	Historical controls, declined transfusions	(n=171), Up to 20U	None reported	Maintained total [Hb], but not RBC [Hb]
Trauma Patients25	Standard hemorrhagic shock resuscitation fluidsb (n=307), PRN	(n=279), Up to 6U	None reported	↑ cardiac adverse effects ↓ PRBC use

^a 1U = 250 mL;

^b Standard hemorrhagic shock resuscitation fluids included volume expanders, crystalloids, colloids, plasma, blood, and vasopressors.

^* = p<0.05. Hb = hemoglobin, RBC = red blood cells, PRBC = packed red blood cells