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. Author manuscript; available in PMC: 2010 Feb 27.
Published in final edited form as: Circ Res. 2009 Jan 15;104(4):476–487. doi: 10.1161/CIRCRESAHA.108.185363

Fig. 3. The effect of miR-221 and miR-222 inhibitor on VSMC proliferation in vitro.

Fig. 3

(A) Knocking down of miR-221 and miR-222 expression by their inhibitors, 2'OMe-miR-221 (100 nM), 2'OMe-miR-222 (100 nM), and 2'OMe-miR-221 plus 2'OMe-miR-222 (100 nM). (B) 2'OMe-miR-222 (100 nM) decreased cell numbers and (C) BrdU incorporation at 48 h after culture with DMEM containing 10% FBS. (D) Representative BrdU-stained cell photomicrographs (top panel), their corresponding total cell photomicrographs stained by DAPI (medial panel) and merged photomicrographs (bottom panel). Note: n=8; *P<0.05 compared with vehicle control.