Table 1.
Number (%) of biopsies and amplification status of epidermal growth factor receptor (EGRF) by fluorescent in situ hybridization (FISH) in different glottic lesions
| Group | Amplification of EGFR gene (%) |
Total | |
|---|---|---|---|
| no | yes | ||
| Control | 31 (100) | 0 (0) | 31 (100) |
| Abnormal hyperplastic lesions | 16 (100) | 0 (0) | 16 (100) |
| Atypical hyperplastic lesions | 19 (90.5) | 2 (9.5) | 21 (100) |
| Squamous carcinoma | 42 (84.0) | 8 (16.0) | 50 (100) |
| Total number of biopsies* | 108 (91.5) | 10 (8.5) | 118 (100) |
*P = 0.045 for controls, abnormal hyperplastic lesions, atypical hyperplastic lesions and squamous carcinomas (χ2 test).