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. 2009 Aug 10;186(3):423–436. doi: 10.1083/jcb.200901105

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© 2009 Winograd-Katz et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jcb.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 6. — Proposed hierarchy of FA morphology regulation. A proposed model for the hierarchy of genes regulating FA morphology. FA growth was found to be regulated by a common molecular pathway, leading to a coordinated increase in the FA's area, length, and paxillin concentration (indicated by the shape and green color intensity). This pathway was inhibited by siRNAs from clusters MC1–4 (the list of siRNAs in this figure is from MC1, which displayed the most striking effect). The concerted regulation of this pathway could be uncoupled by siRNA perturbations, which suggests additional, independent control of individual FA morphology features, as depicted. MC5 siRNAs inhibited the increase in the area and intensity of FA, without disturbing the increase in FA length. MC6 siRNAs affected the pathway, causing an increase in FA area, and MC7 siRNAs increased the percentage of small and round FAs, without affecting paxillin intensity. The siRNAs in the clusters that uncoupled the correlated features are shown together with their “uncoupling factor” in parentheses.