Figure 4.

Mdx mice exhibit tubulin misregulation in the absence of an altered tubulin–MT equilibrium. (A) Representative Western blots of tubulin levels in skeletal muscle extracts from wt and mdx mice. (B) Quantification of tubulin levels from three wt and three mdx extracts. (C) Representative Western blots of tubulin (tub) and MT fractions of skeletal muscle extracts from wt and mdx mice using mAb DM1A. (D) Quantification of tubulin–MT equilibrium from five wt and four mdx tibialis anterior muscles. Loss of dystrophin does not affect the tubulin–MT equilibrium. Error bars represent mean ± SEM.