Table I.
Candidate targets of the RIDD pathway in mouse cells
| Target name | UniGene ID | Localization | Mean log2 (DTT/untreated) | Decreased stability in DTT | |
| hIre1R | Ire1−/− | ||||
| Heparan-α-glucosaminide N-acetyltransferase (Hgsnat) | Mm.28326 | Membrane (lysos.) | −1.34 | 0.45 | Yes |
| Biogenesis of lysosome-related organelles complex-1, subunit 1 (Blos1) | Mm.30118 | Cytosol | −1.22 | −0.10 | Yes |
| Scavenger receptor class A, member 3 (Scara3) | Mm.344095 | Membrane (ER/Golgi) | −1.11 | 0.17 | Yes |
| PDGF receptor (Pdgfrb) | Mm.4146 | Membrane (PM) | −0.89 | 0.12 | Yes |
| Peripheral myelin protein (Pmp22) | Mm.1237 | ECM | −0.88 | −0.07 | Yes |
| Collagen, type VI, α1 (Col6) | Mm.2509 | ECM | −0.85 | −0.15 | Yes |
| Ephrin B2 | Mm.209813 | Membrane (PM) | −1.06 | −0.14 | No |
| Microtubule-associated protein 7 domain containing 1 (MAP7d1) | Mm.266716 | NA | −0.69 | 0.10 | No |
| Splicing factor, Arg/Ser rich 3 (SRp20) | Mm.6787 | Spliceosome | −0.89 | −0.14 | No |
| Tripartite motif protein 16 (Trim16) | Mm.117087 | Cytosol | −0.73 | 0.12 | No |
| Galnt10 | Mm.271670 | Membrane (Golgi) | −0.59 | 0.14 | Yes |
| Laminin B1 subunit 1 | Mm.172674 | ECM | −1.40 | 0.08 | ND |
| Mannose receptor C type 2 | Mm.235616 | Membrane (PM) | −1.14 | −0.17 | ND |
| Leu-rich repeat containing 8C | Mm.319847 | Membrane | −0.99 | −0.17 | ND |
| Neural cell adhesion molecule 1 | Mm.4974 | Membrane (PM) | −0.88 | 0.14 | ND |
| PDGFA-associated protein 1 | Mm.188851 | ECM | −0.88 | −0.21 | ND |
| Syndecan 4 | Mm.3815 | Membrane (PM) | −0.85 | −0.18 | ND |
| Homeo box B4 | Mm.3546 | Nucleus | −0.84 | −0.03 | ND |
| Expressed sequence C79267 | Mm.30464 | NA | −0.77 | −0.12 | ND |
| 3-oxoacid CoA transferase 1 | Mm.13445 | ECM | −0.77 | −0.02 | ND |
| Tripeptidyl peptidase I | Mm.20837 | ECM, mitoch., lysos. | −0.74 | −0.12 | ND |
| RIKEN cDND 4932417H02 | Mm.209933 | NA | −0.71 | 0.21 | ND |
| Pre–B cell leukemia transcription factor–interacting protein 1 | Mm.65906 | NA | −0.69 | 0.33 | ND |
| Chondroitin sulfate proteoglycan 4 (CSP4) | Mm.41329 | Membrane (PM) | −0.68 | 0.28 | ND |
| SHANK-associated RH domain–interacting protein | Mm.41463 | Cytosol | −0.67 | 0.41 | ND |
| ST3 β-galactoside α-2,3-sialyltransferase 5s | Mm.38248 | Membrane (Golgi) | −0.62 | 0.17 | ND |
lysos., lysosomal; mitoch., mitochondria; NA, not applicable (no annotation available); PM, plasma membrane. Localization data are based on Gene Ontology annotations of the mouse genome. Log2 (DTT/untreated) RNA levels were determined by microarray analysis and represent the mean of three independent experiments. Stability data are shown in Fig. S2.