Pharmacokinetic parameters of harmaline in Tg-CYP2D6 and wild-type mice estimated by the pharmacogenetic-based compartmental analysis. CLCYP2D6, clearance contributed by CYP2D6-mediated metabolism; CLother, clearance contributed by other elimination pathways; CLD, distribution clearance between central and peripheral compartments; VC, volume of distribution of the central compartment; VT, volume of distribution of the peripheral compartment; Ka, absorption rate constant; F represents the bioavailability of certain dose of drug administered to different mouse models.