Table 2.

Correlations of indenoisoquinoline activity* to Top1 mRNA and protein levels in the NCI-60 cell line panel.

	Indenoisoquinolines
	NSC 724998†		NSC 725776†		NSC 609699†, Topotecan‡
	Experiment 1	Experiment 2	Experiment 1	Experiment 2
mRNA§	0.258**	0.31**	0.29**	0.32**	0.24
Protein||	0.21	0.27**	0.30**	0.22	0.26

^*Values for GI50 drug activity from the Developmental Therapeutics Program, NCI Web site at http://dtp.nci.nih.gov/dtpstandard/cancerscreeningdata/index.jsp

^†Cancer Chemotherapy National Service Center (NSC) numbers.

^‡Correlations given based on average of 23 independent experiments.

^§mRNA, z score derived from Top1 probes from Affymetrix HG_U95, HG_U133, and HG_U122 Plus2 microarrays.

^||Protein values from ELISA assay in Figure 2.

^**Statistically significant correlation at p < 0.05, without multiple comparisons correction.