Skip to main content
. Author manuscript; available in PMC: 2010 Feb 1.
Published in final edited form as: Eur J Med Chem. 2008 Apr 18;44(2):593–608. doi: 10.1016/j.ejmech.2008.03.040

Figure 4.

Figure 4

(A) 4 in a minimum energy conformation (ΔE= 1.25 kcal/mol) and (B) 1 in a minimum energy conformation (ΔE= 0.92 kcal/mol) are shown here docked in the TMH3-4-5-6 aromatic microdomain within a CB1 TMH bundle model of the R state. The view here is from lipid, looking towards TMHs 3 and 4. TMHs 1, 2 and 7 are not shown in order to simplify the view. Aromatic residues for which each ligand has a direct aromatic stacking interaction are colored orange. Aromatic residues that are part of the extended aromatic cluster, but that do not stack directly with the ligand are colored yellow, while those aromatic residues that have no direct or indirect interaction with the ligand are colored cyan.