Table 4. Ratios of the flip:flop and short:long splice variants for AMPA receptor subunits.
|
AMPA receptor splice variants |
1 week | 4 weeks | 12 weeks | |||
|---|---|---|---|---|---|---|
|
Control |
Diabetic |
Control |
Diabetic |
Control |
Diabetic |
|
| GluR1 flip:flop |
1.19±0.05 |
1.24±0.04 |
1.08±0.02 |
1.06±0.02 |
1.30±0.05 |
1.08±0.03** |
| GluR2-short:long |
37.7±5.0 |
40.5±3.4 |
33.6±1.5 |
54.2±9.1** |
37.6±2.2 |
43.9±2.3 |
| GluR2 flip:flop |
2.69±0.23 |
2.43±0.13 |
2.54±0.24 |
2.71±0.11 |
2.49±0.12 |
2.85±0.16 |
| GluR3 flip:flop |
1.01±0.06 |
1.01±0.05 |
1.13±0.09 |
1.14±0.10 |
1.11±0.08 |
1.03±0.05 |
| GluR4-short:long |
0.72±0.08 |
0.68±0.04 |
0.61±0.04 |
0.61±0.02 |
0.75±0.05 |
0.71±0.05 |
| GluR4 flip:flop | 0.40±0.04 | 0.44±0.03 | 0.51±0.06 | 0.50±0.08 | 0.54±0.07 | 0.63±0.08 |
The ratio is calculated using the normalized expression levels for each isoform for each animal and expressed as the mean±SEM. The double asterisk indicates a p<0.01, and the triple asterisk indicates a p<0.001, significantly different from control, using the two-tailed Student’s t-test.