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(a) One slice of the used clinical images. The lesion is in the rectangle at the lower-left corner of panel A, and the area in the ellipse near the lesion is the reference region. (b) The segmented lesion in 3D space. All the lesion pixels will be analyzed to generate the parametric map. (c) The contrast agent concentration of RR and the lesion pixels after being clustered. The solid curves are fitted from clustered data via Eq. 7.
