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. Author manuscript; available in PMC: 2010 Jun 1.

Published in final edited form as: J Neuropathol Exp Neurol. 2009 Jun;68(6):626–632. doi: 10.1097/NEN.0b013e3181a491ce

A) HoxA5 expression inhibits the growth of EOMA vascular lesions. HoxA5 (upper panels) or control transfected EOMA cells (lower panels) were stereotactically injected into the lateral caudo-putamen of adult CD1 mice and histologically examined 1, 2 and 3 weeks after injection. Photomicrographs show H&E staining of coronal sections at 1 (left side), 2 (middle) and 3 weeks (right side) following transplantation of EOMA+HoxA5 (upper panel) or EOMA cells (bottom panel) into the mouse brain. Tumors derived from HoxA5-expressing EOMA cells, were smaller than those induced by the control transfected EOMA cells. B) Bar graph shows the quantitation of the tumor volume in the EOMA+HoxA5 and EOMA groups at 1, 2, and 3 weeks after transplantation. Data are mean±SD, n=6 in each group. *p<0.05 for the difference between EOMA+HoxA5 vs. EOMA alone group for the same time point.

A) HoxA5 expression inhibits the growth of EOMA vascular lesions. HoxA5 (upper panels) or control transfected EOMA cells (lower panels) were stereotactically injected into the lateral caudo-putamen of adult CD1 mice and histologically examined 1, 2 and 3 weeks after injection. Photomicrographs show H&E staining of coronal sections at 1 (left side), 2 (middle) and 3 weeks (right side) following transplantation of EOMA+HoxA5 (upper panel) or EOMA cells (bottom panel) into the mouse brain. Tumors derived from HoxA5-expressing EOMA cells, were smaller than those induced by the control transfected EOMA cells. B) Bar graph shows the quantitation of the tumor volume in the EOMA+HoxA5 and EOMA groups at 1, 2, and 3 weeks after transplantation. Data are mean±SD, n=6 in each group. *p<0.05 for the difference between EOMA+HoxA5 vs. EOMA alone group for the same time point.