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Locomotor activity of age-matched wild-type and type III Nrg1 heterozygous mice. A, Locomotor activity (mean ± SEM) was measured as total distance traveled (in centimeters). B, Total rears, total jumps, and total stereotypy in a novel open field. Seventeen WT mice (+/+) versus 21 type III Nrg1 heterozygous (+/−) mice were indistinguishable in general activity patterns within 30 min of being placed in the novel open field (5 min bins) (ANOVA: F(1,36) = 0.94, pgenotype = 0.34).
