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. Author manuscript; available in PMC: 2009 Sep 19.
Published in final edited form as: Cell. 2008 Sep 19;134(6):933–944. doi: 10.1016/j.cell.2008.07.048

Figure 4. Systemic palmitoleate metabolism.

Figure 4

A. Free fatty acid and triglyceride flux among ad- ipose, muscle, and liver tissues. Means and SEM of palmitoleate in free fatty acids (FFA) and triglyc- eride (TG) in plasma and adipose, muscle, and liver tissues of WT and FABP. B. Means and SEM of palmitoleate in triglyceride (TG) of WT and FABP−/− mice. C. Model of free fatty acid and triglyceride flux among adipose, muscle and liver tissues. Muscle fatty acids, are mainly derived from liver in the form of VLDL-associated TG and from adipose tissue in the form of FFAs. DNL, de novo lipogenesis; HSL, hormone-sensitive lipase; LPL, lipoprotein lipase. D. Percentile suppression of palmitoleate by HFD in TG fraction of muscle tissue in WT or DK mice. E. Total palmitoleate in liver of WT or DK mice. F. Triglycerides in liver of DK mice injected with control or SCD-1 adenoviruses. Asterisk, p < 0.05.