Table 1.
Characteristics of neuroblastoma survivors and siblings cohorts
| Characteristic | Survivors (n = 954), No. (%) | Siblings (n = 3899), No. (%) | P* |
| Sex | |||
| Male | 455 (48) | 1875 (48) | .83 |
| Female | 499 (52) | 2024 (52) | |
| Vital status at baseline questionnaire | |||
| Alive | 919 (96) | ||
| Dead | 35 (4) | ||
| Age at interview at baseline, y | |||
| <10 | 33 (3) | 76 (2) | <.001 |
| 10–19 | 616 (65) | 1010 (26) | |
| 20–29 | 280 (29) | 1381 (35) | |
| 30–39 | 23 (2) | 1116 (29) | |
| 40–49 | 2 (0) | 316 (8) | |
| Age at interview at latest follow-up, y | |||
| <10 | 10 (1) | 12 (<1) | <.001 |
| 10–19 | 263 (28) | 379 (10) | |
| 20–29 | 519 (54) | 1353 (35) | |
| 30–39 | 155 (16) | 1332 (34) | |
| 40–49 | 7 (1) | 823 (21) | |
| Age at diagnosis, y | |||
| <1 | 525 (55) | NA | |
| 1–4 | 340 (36) | NA | |
| 5–9 | 66 (7) | NA | |
| 10–14 | 15 (2) | NA | |
| 15–21 | 8 (1) | NA | |
| Year of diagnosis | |||
| 1970–1975 | 228 (24) | NA | |
| 1976–1980 | 291 (31) | NA | |
| 1981–1986 | 435 (46) | NA | |
| Survival time at baseline, y | |||
| 5–9 | 103 (11) | NA | |
| 10–14 | 344 (36) | NA | |
| 15–19 | 283 (30) | NA | |
| 20–24 | 187 (20) | NA | |
| >25 | 37 (4) | NA | |
| Survival time at latest follow-up, y | |||
| 5–9 | 32 (3) | NA | |
| 10–14 | 62 (6) | NA | |
| 15–19 | 272 (29) | NA | |
| 20–24 | 298 (31) | NA | |
| >25 | 290 (30) | NA | |
| Treatment group† | |||
| Surgery only | 200 (24) | NA | |
| Surgery + chemotherapy | 216 (26) | NA | |
| Surgery + radiotherapy | 132 (16) | NA | |
| Surgery + chemotherapy + radiotherapy | 268 (32) | NA | |
| Other‡ | 16 (2) | NA | |
*
Survivors and siblings were compared using χ2 tests with bootstrap to account for potential within-family correlations. All statistical tests were two-sided.
†
Based on the 832 patients with medical records abstracted. Of these patients, 20 had bone marrow transplantation in addition to treatment described, including 16 who received total body irradiation.
‡
Among 16 patients who did not have surgery, four had chemotherapy only, three had radiotherapy only, six had both chemotherapy and radiotherapy, and three had no treatment.