A-C) Immunostaining of local tumors for Ki67, showing a reduced amount of proliferation in sl/sl (A) as compared to sl/+ animals (B) and the rescue effect of the transgene in tg sl/sl (C). D-F) H&E staining of lung sections from sl/sl rats (D), showing normal tissue, and sl/+ rats (E) with multiple metastases, similar to the tg sl/sl animals (F). G-I) Immunostaining of the local tumors for the rat macrophage antigen ED-2, demonstrating lower numbers of infiltrating TAM in sl/sl animals (G) than in sl/+ (H) and tg sl/sl rats (I). Sections of tumors and metastases from +/+ animals are not shown separately, since they did not differ from the sl/+ samples.