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. 2009 Aug 27;4(8):e6797. doi: 10.1371/journal.pone.0006797

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Honig et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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A. 5-HT forebrain content in mice treated chronically with CIT or vehicle. 5-HT content was not significantly affected by CIT treatment at any single time point (p>0.05, Bonferroni post-ANOVA test). However, CIT treatment caused a significant overall reduction in 5-HT as determined by ANOVA (p<0.05). Numbers of mice: 2-day CIT-treated, n = 8; 2-day SAL-treated, n = 8; 2-week CIT-treated, n = 8; 2-week SAL-treated, n = 9; 4-week CIT-treated, n = 7; 4-week SAL-treated, n = 7. B. 5-HT forebrain content in mice treated chronically with CIT or vehicle and acutely with NSD-1015 (100 mg/kg IP) 30 minutes before sacrifice. Forebrain 5-HT content was reduced in mice treated with CIT for 2 weeks (*p<0.01, Bonferroni post test) and 4 weeks (*p<0.01) but not 2 days (p>0.05). Numbers of mice: 2-day CIT-treated, n = 6; 2-day SAL-treated, n = 6; 2-week CIT-treated, n = 8; 2-week SAL-treated, n = 7; 4-week CIT-treated, n = 7; 4-week SAL-treated, n = 10.