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. 2009 Aug 27;4(8):e6797. doi: 10.1371/journal.pone.0006797

Figure 3. Reduced forebrain 5-HIAA in mice treated with CIT.

Figure 3

A. 5-HIAA forebrain content in mice treated chronically with CIT or vehicle. 5-HIAA content was significantly lower in mice treated with CIT for 2 days (*p<0.001, Bonferroni post-ANOVA test) or 2 weeks (**p<0.01) but not 4 weeks (p>0.05). Numbers of mice: 2-day CIT-treated, n = 8; 2-day SAL-treated, n = 8; 2-week CIT-treated, n = 8; 2-week SAL-treated, n = 9; 4-week CIT-treated, n = 7; 4-week SAL-treated, n = 7. B. 5-HIAA forebrain content in mice treated chronically with CIT or vehicle and acutely with NSD-1015 (100 mg/kg IP) 30 minutes before sacrifice. 5-HIAA content was lower in CIT-treated mice at all time points (*p<0.001, Bonferroni post-ANOVA test). Numbers of mice: 2-day CIT-treated, n = 6; 2-day SAL-treated, n = 6; 2-week CIT-treated, n = 8; 2-week SAL-treated, n = 7; 4-week CIT-treated, n = 7; 4-week SAL-treated, n = 10.