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. Author manuscript; available in PMC: 2010 Sep 1.
Published in final edited form as: Exp Neurol. 2009 May 5;219(1):93–103. doi: 10.1016/j.expneurol.2009.04.026

Figure 4. CGRP immunoreactivity in L1 and S1 spinal cord before and during colitis.

Figure 4

CGRP immunoreactivity (IR) was mainly present in the superficial laminae (I-II) of the dorsal horn in both control and colitic animals (* in a, b, g, and i). In L1 spinal cord, colitis was associated with the increases in the density of CGRP-IR at the dorsal horn region (compare b to a, *), increases in the density of CGRP-IR fibers extending toward the central commissure (compare d to c, arrows), and increases in the number of CGRP neurons in the area of intermediolateral cell column (compare f to e, arrow). In S1 spinal cord, colitis causes decreases in the density of CGRP-IR in dorsal horn (compare i to h, *), but increases in CGRP-IR fibers in a location resembling the Lissauer’s tract. Dotted lines in a and b indicate the borders between gray and white matters in the spinal cord. Calibration bar = 200 μm in a, b; 80 μm in c, e, d, and f; 160 μm in h and i.