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. Author manuscript; available in PMC: 2009 Sep 1.
Published in final edited form as: Exp Neurol. 2009 May 13;219(1):146–155. doi: 10.1016/j.expneurol.2009.05.006

Figure 2.

Figure 2

Nerve degeneration in the tumor bearing hindpaws. (A) Hematoxylin-eosin (HE) staining of hindpaw skin (plantar surface) 9 days after tumor inoculation. The tumor tissue (indicated with *) was located in the dermis. Scale bar, 400 μm. (B) PGP-9.5 immunostaining of hindpaw skin (plantar surface) reveals a loss of nerve fibers 9 days after tumor inoculation. Arrows indicated nerve fibers in the epidermis. (C) ATF-3 immunostaining indicates induction of ATF-3 in the nuclei of many DRG neurons after tumor inoculation. Scale bar, 100 μm. (D) pJNK immunostaining shows JNK activation in DRG neurons after tumor inoculation. Scale bar, 50 μm.