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. 2009 Aug 18;339:b3170. doi: 10.1136/bmj.b3170

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This is an open-access article distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license. See: http://creativecommons.org/licenses/by-nc/2.0/ and http://creativecommons.org/licenses/by-nc/2.0/legalcode.

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graphic file with name jenc595884.f1_default.jpg — Flow of participants through trial. All those randomised contribute to multiple imputation to follow intention to treat principle. Responders are those returning an outcome. Responders at 24 months contribute to complete case analysis. In each treatment group, categories at each time point are not mutually exclusive as some people who withdrew, returned an outcome