Table 1.

Risk Factors for Psychotic Disorders

Time of Assessment	Risk Factor	Examples
At any time	Genes	DISC1
	Family history	50% concordance for MZ twins
	Gender	Bimodal risk profile in females
	Culture	Immigrant status
	Living environment	Urbanicity
Distal to illness onset	Abnormal fetal development	Maternal malnutrition
	Abnormal cognitive development	Low IQ
	Early drug use	MJ before age 13
Proximal to illness onset	Mental status changes	Attenuated psychotic symptoms, basic symptoms
	Biomarker	Decrease of cortical gray matter, elevated DA release

Note: This list of risk factors is not exhaustive but is meant to illustrate 3 different types of risk factors. MZ, monozygotic; MJ, marijuana; DA, dopamine.