Table 2.

Comparison between microRNA expression in primary brain tumors and expression in other primary tumors or expression in brain metastases, based on microRNA microarray data. Abbreviation: AUC = area under curve.

Primary brain vs.	Other primary tumors			Brain metastases
	P‐value†	fold‐change‡	AUC	P‐value†	fold‐change‡	AUC
hsa‐miR‐124	1.4E‐54	97.1	0.9975	5.4E‐06	12.6	0.8600
hsa‐miR‐219‐5p	9.7E‐43	10.0	0.9679	4.1E‐09	6.9	0.8840
C0 †	1.8E‐49	293.0	1.0000	9.0E‐09	27.7	0.8987
hsa‐miR‐128	5.4E‐27	9.3	0.9929	4.5E‐11	4.2	0.9507
hsa‐miR‐9*	1.4E‐64	31.3	1.0000	9.1E‐22	18.9	0.9933
hsa‐miR‐92b	1.8E‐26	7.3	0.9993	2.1E‐18	5.8	1.0000
C1 †	1.7E‐57	205.9	1.0000	3.3E‐26	128.7	1.0000

^† P‐values are calculated on log‐signal of microRNAs, and on C₀ and C₁ (methods), which are in log‐space. Less that 1000 probes were tested, and even after the more severe Bonferroni correction (multiplying each P‐value by ∼1000), the P‐values remain highly significant.

^‡ The fold change is calculated by dividing the median signal in brain primary tumors by the median signal in other tissues.