Table 3.

Comparison between microRNA expression in primary brain tumors and expression in other primary tumors or expression in brain metastases, based on microRNA qRT‐PCR data. Abbreviation: AUC = area under curve.

Primary brain vs.	Other primary tumors			Brain metastases
	P‐value†	fold‐change‡	AUC	P‐value†	fold‐change‡	AUC
hsa‐miR‐124	4.7E‐9	2144	1.0000	1.4E‐4	48	0.8633
hsa‐miR‐9	2.3E‐11	17 648	1.0000	2.0E‐11	543	0.9833
hsa‐miR‐9*	1.5E‐11	1887	1.0000	1.4E‐12	415	0.9922
hsa‐miR‐92b	1.7E‐6	16	0.9542	7.2E‐7	8	0.9219
CRT	1.1E‐10	2.9E+5	1.0000	7.7E‐12	9993	0.9961
CRT*	2.8E‐10	11 868	1.0000	6.4E‐12	2428	1.0000

^† P‐values are calculated on measured C_t values and on C^RT and C^RT* (methods), which are in log‐space. Here only the listed four potential biomarkers and two combinations were tested, and no correction for multiple hypothesis testing is needed.

^‡ The fold change is calculated by converting the data to linear space (by taking the exponent base 2) and dividing the median signal in brain primary tumors by the median signal in other tissues.