Fig. 3.

H247-BeF₃⁻ human NAMPT in complex with NMN and Mg₂PPi. (A) 1.8 Å 2F_o–F_c electron density map contoured at 1σ level around H247-BeF₃⁻ (blue); Mg²⁺ atoms are depicted as gray spheres. (B) Interactions for the NAM, ribose and BeF₃⁻ moieties, with 2 monomers presented in yellow and cyan. NMN is colored in black, Be is in lemon, and F in light blue. Blue dashed lines represent Mg²⁺ coordination. Red spheres represent water molecules and the olive dashed lines represent the corresponding hydrogen bonds involved. (C) The main interactions for the diphosphate moiety. The green dashed line represents distance d₂ as summarized in Table 1. Produced with PyMol v 1.1.