Fig. 4.

H247-BeF₃⁻ human NAMPT in complex with Mg₂PRPP and BzAM. (A) Final 2F_o−F_c electron density map for H247-BeF₃⁻ at 1.9 Å. The contour level (blue) is at 1σ; gray spheres correspond to Mg²⁺ atoms. (B) Interactions for the BzAM, ribose and BeF₃⁻ moieties. The 2 monomers are depicted in yellow and cyan, while PRPP·BzAM is colored in black, Be is in lemon, and F represented in light blue. Blue dashed lines represent the Mg²⁺ coordination while the green dashed line represents distance d₁ as summarized in Table 1. Water molecules and the corresponding hydrogen bonds are depicted as red spheres and olive dashed lines, respectively. (C) Interactions for the diphosphate moiety. Produced with PyMol v 1.1.