Fig. 6.

Effect of wortmannin on the survival of mice following challenge with B. anthracis spores. Kaplan–Meier plots of the survival of mice after SC administration of 5 × 10⁵ wt spores and vehicle, or wt spores and wortmannin (0.5 mg/kg). (Top) C57BL/6 mice. The difference in survival is not statistically significant (P = 0.6768, Log-rank test). (Middle) CD11b^−/− mice. The difference in survival is not statistically significant (P = 0.9688, Log-rank test). (Bottom) CD14^−/− mice. The difference in survival is statistically significant (P = 0.0017, Log-rank test).