Table 2.

Association of serum sodium concentration with presence of the TRPV4^P19S allele

Cohort	Covariates	Sex	n	Association, P value	Prevalence ratio for hyponatremia
Healthy Aging	Age, glucose	M	76	0.0024	6.45 (1.22–34.25); P = 0.029
		F	130	0.40	1.76 (0.52–6.0); P = 0.37
MrOS	Age, glucose, creatinine, recruitment center	M	1,300	0.019	2.43 (1.17–5.06); P = 0.017

Strength of association of serum sodium concentration with presence of the TRPV4^P19S allele in non-Hispanic Caucasian subjects genotyped in the Healthy Aging and MrOS cohorts, as tested via linear regression analysis on available covariates (shown) and stratified by sex (see Methods). For the Healthy Aging cohort, subjects with missing age data (n = 2) were excluded from this analysis; in addition, subjects with serum glucose ≥150 mg/dL (n = 11) were excluded to maintain consistency with inclusion criteria for the genotyped MrOS cohort. Prevalence ratios (and 95% confidence intervals) were calculated for the presence of hyponatremia (serum sodium concentration ≤135 mEq/L) as a function of the presence of the TRPV4^P19S allele, and incorporating available covariates. Male subjects with the TRPV4^P19S allele in the Healthy Aging and MrOS cohorts were 6.45 and 2.43 times as likely, respectively, to exhibit hyponatremia as were subjects lacking the allele.