Fig. 3.

Body temperature, NREMS, SWA, and REMS of preproghrelin WT mice during the course of the experiment. Experimental manipulations induced significant changes in body temperature and sleep of preproghrelin WT mice. The direction of these changes was similar to those seen in KO mice, but the magnitude was significantly attenuated. Body temperature of preproghrelin WT mice was suppressed during the first day of cold exposure and during the fasting day. NREMS was attenuated during the dark phases of cold days 1, 2, and 3 and throughout the fasting day. REMS was suppressed during the first dark period and during the fasting day. See legends to Figs. 1 and 3 for statistics and details.