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Stimulation of MMP-2 expression in ARPE-19 cells by CTGF. (A) RT-qPCR analyses show significant increase of MMP-2 expression in CTGF-treated ARPE-19 cells. Statistically significant differences, compared with the control. (B, top) Western blot from a representative experiment. CTGF significantly increased protein levels of MMP-2 in the supernatants of ARPE-19 cells. (C, D) Blockade of CTGF by FG-3019 inhibited CTGF-induced mRNA expression (C) and protein production (D) of MMP-2.
