Inhibition of fibronectin (A, D), laminin (B, E), and MMP-2 (C, F) expression by an ERK1/2 inhibitor. (A–C) RT-qPCR analyses show significant suppression of fibronectin (A), laminin (B), and MMP-2 (C) expression by the MEK-1 inhibitor, PD98059. (D–F) Top: Western blot from a representative experiment. Bottom: graphical representation of differences compared with the vehicle control. Statistically significant differences are indicated. PD, ERK1/2 inhibitor PD098059; SB, p38 MAPK inhibitor SB203580.