Table 2.
Enriched biological processes differentially regulated by R5020
| ADULT GO CATEGORIES | |||
|---|---|---|---|
| Biological Process | Count | % | p-value |
| defense response | 13 | 12.4 | 1.9 E-4 |
| cell adhesion | 11 | 10.5 | 1.6 E-3 |
| immune response | 9 | 8.6 | 5.4 E-3 |
| steroid metabolic process | 5 | 4.8 | 6.9 E-3 |
| response to wounding/external stimulus | 8 | 7.6 | 1.0 E-2 |
| ossification/bone remodeling | 4 | 3.8 | 1.1 E-2 |
| regulation of cell differentiation | 5 | 4.8 | 1.2 E-2 |
| protein homooligomerization | 3 | 2.9 | 1.3 E-2 |
| negative regulation of apoptosis | 5 | 4.8 | 1.4 E-2 |
| tissue development | 6 | 5.7 | 1.6 E-2 |
| response to stimulus | 26 | 24.8 | 1.8 E-2 |
| response to stress | 10 | 9.5 | 2.0 E-2 |
| arginine catabolic/metabolic process | 2 | 1.9 | 2.4 E-2 |
| behavior | 6 | 5.7 | 2.4 E-2 |
| amino acid catabolic process | 3 | 2.9 | 2.6 E-2 |
| negative regulation of biological process | 11 | 10.5 | 2.7 E-2 |
| reproduction | 7 | 6.7 | 3.1 E-2 |
| cell activation | 5 | 4.8 | 3.4 E-2 |
| carboxylic acid metabolic process | 7 | 6.7 | 3.7 E-2 |
|
PUBERTAL GO CATEGORIES | |||
| Biological Process | Count | % | p-value |
|
| |||
| immune system process | 15 | 9 | 7.1 E-3 |
| apoptosis | 13 | 7.8 | 7.4 E-3 |
| catabolic process | 12 | 7.2 | 8.7 E-3 |
| regulation of cell adhesion | 4 | 2.4 | 1.0 E-2 |
| kidney development | 4 | 2.4 | 1.9 E-2 |
| male sex differentiation | 3 | 1.8 | 2.3 E-2 |
| cytokine biosynthetic process | 4 | 2.4 | 2.3 E-2 |
| organ development | 19 | 11.4 | 2.6 E-2 |
| defense response | 12 | 7.2 | 2.7 E-2 |
| leukocyte migration | 3 | 1.8 | 3.0 E-2 |
| protein homooligomerization | 3 | 1.8 | 3.0 E-2 |
| inorganic anion transport | 5 | 3 | 3.7 E-2 |
| small GTPase mediated signal transduction | 8 | 4.8 | 4.0 E-2 |
| response to wounding/external stimulus | 9 | 5.4 | 4.1 E-2 |
| multi-organism process | 6 | 3.6 | 5.0 E-2 |
Significantly enriched Gene Ontology (GO) terms (only biological processes) for genes regulated by R5020 in adult and pubertal organoids as determined by analysis with Database for Annotation, Visualization and Integrated Discovery (DAVID) software (P<0.05). The count is the number of R5020-regulated genes in each category. The percentage is the proportion of R5020-regulated genes among the total genes in each category. P-value is the threshold of EASE Score, a modified Fisher Exact P-Value used for gene-enrichment analysis ranging from 0 to 1, where a P-Value of 0 represents a perfect enrichment.