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. Author manuscript; available in PMC: 2009 Aug 19.
Published in final edited form as: Nat Genet. 2009 Jan 18;41(2):178–186. doi: 10.1038/ng.298

Figure 5.

Figure 5

Genes downregulated in association with T-DMR shore hypermethylation are activated by 5-aza-2′-deoxycytidine treatment of colon cancer cell line HCT116 and knockout of DNA methyltrasferase 1 and 3b in HCT116. (a) Genes significantly upregulated (p<0.05) after treatment of HCT116 cells with 5-aza-2′-deoxycytidine (AZA) (black) that are also associated with a relatively hypermethylated T-DMR showing a significant change in gene expression (p<0.05) (grey). 24/28 genes are activated by AZA. (b) Genes significantly upregulated (p<0.05) after knockout of DNA methyltransferases 1 and 3b (DKO) in HCT116 cells (black) that are also associated with a relatively hypermethylated T-DMRs showing a significang change in gene expression (p<0.05) (grey). 25/25 genes are activated by DKO. Plotted are log (base 2) ratios of expression of AZA/untreated, DKO/HCT116, and relatively hypermethylated/hypomethylated tissue.