Table 2.

Evaluation of intraday precision and accuracy for bisoprolol spiked quality control samples.

Cth = 3 ng/mL			Cth = 25 ng/mL		Cth = 75 ng/mL
	Cexp (ng/mL)	% nominal	Cexp (ng/mL)	% nominal	Cexp (ng/mL)	% nominal
(1)	2.912	98.391	22.524	91.263	69.203	93.468
(2)	3.003	101.439	24.862	100.737	68.525	92.552
(3)	3.262	110.192	23.762	96.281	66.781	90.196
(4)	2.829	95.568	25.189	102.062	76.691	103.580
(5)	3.018	101.960	21.739	88.085	65.844	88.931
(6)	2.854	96.431	21.371	86.593	74.009	99.958
Mean	2.980	100.664	23.241	94.170	70.176	94.781
SD	0.158		1.610		4.268
CV %	5.296		6.927		6.082
		Acceptance criteria
		67% Total QCs must be 100 ± 15% nominal values
		50% QCs per level must be 100 ± 15% nominal values
		Mean % nominal 100 ± 15%
		CV (%) ≤ 15%

C_th = theoretical concentration. C_exp = experimental concentration. SD = standard deviation. CV % = coefficient of variation