Fig. 8.

Summary of Atoh1-dependent cell types in the developing spinal cord, including time of migration and location along the rostral-caudal axis. DP1 progenitors express Atoh1 (A), migrating precursors have inactivated Atoh1 but express Lhx2/9 (B), and in turn activate Lhx1/5 upon arrival in the intermediate gray (C). Moreover, medial vs. lateral cell clusters may be identified by the expression of Smarca2 and TAG. At E13.5 a new Atoh1 progenitor domain is identified (D). Some of these cells become SOX9⁺ in the absence of Atoh1. See text for details.