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. Author manuscript; available in PMC: 2010 Feb 1.
Published in final edited form as: Otol Neurotol. 2009 Feb;30(2):131–138. doi: 10.1097/mao.0b013e318191bff8

Figure 5.

Figure 5

Heavy curves in panels A and B show TMPA concentration measured with TMPA-selective electrodes in third turn of scala vestibuli in two separate experiments when the bulla was filled with 40 mM TMPA solution. In each case, TMPA concentration started increasing within 5 minutes of the application, which is far faster than expected if entry occurred only through the round window membrane. The fine curves show simulations of the experiments based on a communication between perilymph and the middle ear (representing entry through the bone) with half-times of 1100 mins (Panel A) and 360 minutes (Panel B) respectively.