Table 2.
Changes in biochemical parameters between baseline and 12 months in placebo and DHEA-treated groups
| Parameter | DHEA
|
Placebo
|
P valuea | ||
|---|---|---|---|---|---|
| Baseline | 12 months | Baseline | 12 months | ||
| Androstenedione (nmol/liter) | 1.56 (0.2) | 4.2 (0.3) | 1.68 (0.2) | 1.6 (0.3) | <0.001 |
| Testosterone (nmol/liter) | |||||
| Male | 17.8 (1.3) | 16.5 (1.2) | 16.2 (1.1) | 14.2 (0.9) | 0.39 |
| Female | 0.21 (0.03) | 0.41 (0.05) | 0.14 (0.02) | 0.13 (0.02) | <0.001 |
| Estradiol (nmol/liter) | |||||
| Male | 118.9 (6.8) | 109.6 (6.3) | 105.5 (4.3) | 102.9 (4.3) | 0.95 |
| SHBG(U/liter) | |||||
| Male | 35.7 (3.0) | 38.8 (3.2) | 36.0 (3.6) | 38.4 (3.8) | 0.90 |
| Female | 67.9 (7.9) | 63.7 (7.2) | 78.9 (7.7) | 81.7 (7.4) | 0.33 |
| Lipids (nmol/liter) | |||||
| Cholesterol | 4.45 (0.22) | 4.62 (0.16) | 4.63 (0.19) | 4.57 (0.18) | 0.36 |
| Triglycerides | 1.23 (0.14) | 1.30 (0.12) | 1.43 (0.14) | 1.56 (0.15) | 0.38 |
| HDL | 1.27 (0.08) | 1.43 (0.06) | 1.26 (0.07) | 1.36 (0.06) | 0.27 |
| LDL | 2.57 (0.15) | 2.65 (0.12) | 2.78 (0.15) | 2.55 (0.14) | 0.15 |
| IGF-I (nmol/liter) | |||||
| Male | 26.8 (1.8) | 25.2 (1.9) | 25.0 (2.0) | 23.7 (1.7) | 0.64 |
| Female | 23.7 (1.6) | 25.0 (1.9) | 22.5 (1.5) | 20.9 (1.3) | 0.01 |
Data shown are mean (sem).
a
P value relates to the comparison of 12-month values, adjusted for baseline, between DHEA and placebo groups.