Table 1.
TSH distribution using the ELISA for the entire cohort and by NRG
TSH (μIU/ml)
|
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n | Mean | sd | Median | Minimuma | Maximum | 2.5th percentileb | 97.5th percentileb | |
All | 1861 | 1.81 | 2.78 | 1.35 | <0.04 | 88.7 | 0.25 | 5.67 |
Males | 895 | 1.58 | 1.67 | 1.22 | <0.04 | 26.3 | 0.44 | 4.40 |
Females | 966 | 2.01 | 3.49 | 1.47 | <0.04 | 88.7 | 0.06 | 6.50 |
NRG-1c | 1448 | 1.54 | 0.82 | 1.35 | 0.32 | 4.98 | 0.52 | 3.73 |
Males | 779 | 1.43 | 0.78 | 1.22 | 0.33 | 4.80 | 0.50 | 3.73 |
Females | 669 | 1.67 | 0.84 | 1.49 | 0.32 | 4.98 | 0.54 | 3.76 |
NRG-2c | 1186 | 1.45 | 0.73 | 1.30 | 0.32 | 4.79 | 0.53 | 3.37 |
Males | 673 | 1.39 | 0.73 | 1.21 | 0.36 | 4.79 | 0.52 | 3.38 |
Females | 513 | 1.53 | 0.72 | 1.40 | 0.32 | 4.05 | 0.53 | 3.37 |
NRG-3c | 766 | 1.48 | 0.74 | 1.32 | 0.36 | 4.79 | 0.54 | 3.37 |
Males | 480 | 1.41 | 0.73 | 1.24 | 0.36 | 4.79 | 0.54 | 3.28 |
Females | 286 | 1.61 | 0.75 | 1.47 | 0.38 | 4.05 | 0.55 | 3.37 |
There were 18 female subjects and one male subject with TSH by ELISA less than 0.04.
Percentiles were estimated nonparametrically, not from fitted Gaussian or lognormal distributions.
NRG-1 excludes those with thyroid disease, on thyroid hormone, and on medications that may affect thyroid function (lithium, amiodarone, glucocorticoids, Dilantin, Tegretol). NRG-2 additionally excludes those with positive antithyroid peroxidase or positive antithyroglobulin, and NRG-3 additionally excludes those with thyroid ultrasound abnormalities.