Table 5.
Odds ratios (95% CI)1 for colorectal adenoma recurrence, by obesity and waist circumference stratified by family history of colorectal cancer.
| Family History of Colorectal Cancer2 | ||||||||
|---|---|---|---|---|---|---|---|---|
| No | Yes | |||||||
| BMI Category3 |
No. recur/ total |
Recurrence | No. recur/ total |
Advanced Recurrence |
No. recur/ total |
Recurrence | No. recur/ total |
Advanced Recurrence |
| Normal Weight | 257/588 | 1.00 | 81/412 | 1.00 | 59/151 | 1.00 | 24/116 | 1.00 |
| Overweight | 407/861 | 1.01 (0.80–1.27) | 143/597 | 1.13 (0.81–1.58) | 124/259 | 1.35 (0.86–2.12) | 44/179 | 1.30 (0.67–2.53) |
| Obese | 210/474 | 1.00 (0.77–1.31) | 60/324 | 0.91 (0.61–1.36) | 77/132 | 2.25 (1.32–3.84) | 25/80 | 1.95 (0.90–4.21) |
| p-trend4 | 0.78 | 0.77 | 0.006 | 0.06 | ||||
| Waist Category5 | ||||||||
| Small | 208/475 | 1.00 | 72/339 | 1.00 | 49/116 | 1.00 | 18/85 | 1.00 |
| Medium | 189/433 | 0.92 (0.69–1.22) | 51/295 | 0.73 (0.48–1.12) | 58/130 | 1.00 (0.57–1.74) | 26/98 | 1.11 (0.51–2.46) |
| Large | 206/446 | 0.95 (0.72–1.26) | 73/313 | 0.96 (0.64–1.42) | 68/123 | 1.67 (0.95–2.94) | 25/80 | 1.68 (0.76–3.75) |
| Extra Large | 197/409 | 1.10 (0.82–1.46) | 59/271 | 0.98 (0.65–1.49) | 63/129 | 1.56 (0.88–2.77) | 17/83 | 1.26 (0.54–2.91) |
| p-trend4 | 0.5 | 0.81 | 0.04 | 0.27 | ||||
1
Models adjusted for age, gender, previous polyps, number of adenomas at baseline, and study.
2
Family history of colorectal cancer in one or more first degree relative.
3
BMI categories are normal weight, > 18.5 and <25; overweight >=25.0 and <30; and obese >30 inches.
4
P-trend calculated with logistic regression modeling with the categorical variable for body size as the independent variable.
5
Waist cutpoints for men (inches) small <36.5; medium 36.5–39.0; large 39.1–42.0; extra-large >42. Waist cutpoints for women (in) small <30.0; medium 30.0–33.0; large 33.2–37.0; extra-large >37.0.