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. 2008 May 28;28(22):5731–5739. doi: 10.1523/JNEUROSCI.4431-07.2008

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Copyright © 2008 Society for Neuroscience 0270-6474/08/285731-09$15.00/0

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Figure 5. — Coexpression of Kv1 channel α-subunits with PSD-93 results in the formation of large surface clusters of Kv1 channels in COS7 cells. The cDNAs used in the transfections are listed to the left of each set of images. A, Kv1.1 transfected cells labeled with antibodies against extracellular (Kv1.1ext) or intracellular (Kv1.1int) epitopes. B, C, Coexpression of Kv1.1 with Kv1.2 or Kv1.4 α-subunits promotes the uniform surface expression of Kv1.1. D, E, PSD-95 or PSD-93 transfected COS7 cells reveal a uniform cytoplasmic staining for the introduced MAGUK. F, G, Coexpression of Kv1.1 with Kv1.2 (F) or Kv1.4 (G) and PSD-95 results in the formation of large Kv1 channel surface clusters. Kv1.1 was detected using the Kv1.1ext antibody. H, I, Coexpression of Kv1.1 with Kv1.2 (H) or Kv1.4 (I) and PSD-93 results in the formation of large Kv1 channel surface clusters. Kv1.1 was detected using the Kv1.1ext antibody. Scale bar, 10 μm.