Table 1.
Calcium (mg/dl)
|
|||
---|---|---|---|
0 month | 6 months | 12 months | |
PBO | 10 (0.4) | 10 (0.4) | 10 (0.4) |
Low dose (1,400 IU/wk) | 9.9 (0.3) | 10 (0.4) | 10 (0.3) |
High dose (14,000 IU/wk) | 9.9 (0.4) | 10 (0.4) | 10 (0.3) |
Phosphorus (mg/dl)
|
|||
---|---|---|---|
0 month | 6 months | 12 months | |
PBO | 4 (0.5) | 4.6 (0.5) | 4.5 (0.6) |
Low dose (1,400 IU/wk) | 4.3 (0.5) | 4.4 (0.8) | 4.5 (0.6)a |
High dose (14,000 IU/wk) | 4.3 (0.7) | 4.4 (0.6) | 4.5 (0.6)a |
Alkaline phosphatase (IU/liter)
|
|||
---|---|---|---|
0 month | 6 months | 12 months | |
PBO | 199 (116) | 160 (83) | 145 (76)a |
Low dose (1,400 IU/wk) | 208 (112) | 192 (103) | 172 (93)a |
High dose (14,000 IU/wk) | 232 (139) | 198 (115) | 176 (102)a |
25-OHD (ng/ml)
|
|||
---|---|---|---|
0 month | 6 months | 12 monthsb | |
PBO | 14 (7) | 16 (8)a | |
Low dose (1,400 IU/wk) | 14 (9) | 17 (6)a | |
High dose (14,000 IU/wk) | 13 (8) | 38 (31)a |
1,25-OHD (pg/ml)
|
|||
---|---|---|---|
0 month | 6 months | 12 monthsb | |
PBO | 86 (30) | 76 (30)a | |
Low dose (1,400 IU/wk) | 78 (29) | 78 (29) | |
High dose (14,000 IU/wk) | 83 (27) | 104 (33)a |
Biochemical assays are reported in metric units. To convert from metric to SI units, multiply calcium by 0.25 (millimoles per liter); phosphorous by 0.32 (millimoles per liter); 25-OHD by 2.496 (nanomoles per liter); and 1,25-OHD by 2.6 (picomoles per liter).
P < 0.001 between 0 and 12 months by paired t test.
P < 0.05 by one-way ANOVA between treatment groups: P < 0.0001 between PBO and high; P < 0.0001 between high and low.