Table 4.
Adjusteda pooled odds ratios (95% confidence intervals) for melanoma in women in relation to number of nevi, stratified by anatomical site of melanoma
| Head & Neck b | Trunk b | Lower Limbs b | Upper Limbs b | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cases | Controls | p OR(95% CI) | Cases | Controls | p OR (95% CI) | Cases | Controls | p OR (95% CI) | Cases | Controls | p OR (95% CI) | |
| Any nevi, palpable or flat, single upper limb | ||||||||||||
| None (ref) | 48 | 738 | 1.0 | 74 | 738 | 1.0 | 148 | 721 | 1.0 | 64 | 738 | 1.0 |
| 1–4 | 83 | 625 | 1.7 (1.0–2.8) | 179 | 625 | 2.1 (1.4–3.1) | 225 | 504 | 2.3 (0.6–9.3) * | 98 | 625 | 1.7 (0.6–4.7) * |
| 5–10 | 32 | 167 | 1.8 (0.7–4.7) | 90 | 184 | 4.0 (2.2–7.2) | 77 | 122 | 4.0 (1.6–10.1) * | 49 | 114 | 3.9 (1.9–8.3) |
| >10 | 30 | 204 | 1.9 (0.8–4.9) | 127 | 207 | 5.0 (2.7–9.3) | 84 | 154 | 2.8 (1.6–4.9) | 78 | 204 | 4.8 (2.5–9.5) |
| None (ref) | 37 | 659 | 1.0 | 71 | 629 | 1.0 | 144 | 642 | 1.0 | 58 | 659 | 1.0 |
| Q1 | 35 | 348 | 1.3 (0.6–2.9) | 87 | 317 | 1.6 (0.9–2.9) | 79 | 276 | 1.2 (0.4–3.5) * | 43 | 348 | 1.3 (0.6–2.4) |
| Q2 | 25 | 125 | 1.3 (0.5–3.1) | 62 | 141 | 1.9 (1.0–3.4) | 49 | 141 | 1.4 (0.8–2.5) | 31 | 74 | 2.1 (1.1–4.2) |
| Q3 | 23 | 131 | 1.7 (0.6–4.3) | 94 | 134 | 2.8 (1.5–5.2) | 78 | 134 | 2.2 (0.6–8.2) * | 37 | 131 | 1.8 (0.8–4.1) |
| Q4 | 35 | 252 | 2.0 (0.9–4.5) | 152 | 252 | 4.6 (2.7–7.6) | 144 | 196 | 3.4 (1.5–7.9) * | 90 | 252 | 4.2 (2.3–7.5) |
| Per unit increase in nevus number | 167 | 1640 | 1.01 (0.98–1.05) | 450 | 1640 | 1.02 (1.00–1.05) | 261 | 1640 | 1.01 (1.00–1.02) | 506 | 1640 | 1.01 (1.00–1.02) |
| trend p=0.25 | trend p=0.0004 | trend p=0.01 | trend p=0.01 | |||||||||
*
Significant heterogeneity, random effects model used (see text).
a
Adjusted for age, skin type and family history of melanoma
b
Numbers may not sum to total because of missing data; when there are zero cells in a stratum for a study, that study drops from the pooled analysis for that stratum