Table 3.
The down-regulated DEGs sharing from cirrhosis to metastasis sorted out by the following GO function.
| Gene Symbol | Gene Title | GO |
| COL18A1 | procollagen, type XVIII, alpha 1 | 1–6 |
| CXCL12 | chemokine (C-X-C motif) ligand 12 | 1,2,4,5 |
| KDR | kinase insert domain protein receptor | 1,4,6 |
| SERPINA3K | serine (or cysteine) peptidase inhibitor, clade A, member 3K | 1,2,5 |
| ANG1 | angiogenin, ribonuclease A family, member 1 | 1,5 |
| RNASE4 | ribonuclease, RNase A family 4 | 1,5 |
| C5 | complement component 5 | 2,4 |
| CML4 | Camello-like 4 | 3 |
| ENPP2 | ectonucleotide pyrophosphatase/phosphodiesterase 2 | 3 |
| GPHN | gephyrin | 3 |
| IGFALS | insulin-like growth factor binding protein, acid labile subunit | 3 |
| LIN7A | lin-7 homolog a (C. elegans) | 3 |
| AZGP1 | alpha-2-glycoprotein 1, zinc | 3,5 |
| PROC | Protein C | 2 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | 3 |
| PVRL3_predicted | poliovirus receptor-related 3 (predicted) | 3 |
| SORL1 | sortilin-related receptor, LDLR class A repeats-containing | 4,5 |
| TGFBI | transforming growth factor, beta induced | 3,4,6 |
| RB1 | retinoblastoma 1 | 2,3,5 |
| EGFR | epidermal growth factor receptor | 2–6 |
| EGF | epidermal growth factor | 2,5,6 |
| IGF1 | Insulin-like growth factor 1 | 2,5,6 |
| HNF4A | Hepatocyte nuclear factor 4, alpha | 2,5 |
| BCL6_PREDICTED | B-cell leukemia 6 (predicted) | 2,5 |
| PEMT | phosphatidylethanolamine N-methyltransferase | 2,5 |
| LRP1 | low density lipoprotein receptor-related protein 1 | 2,5 |
| RGN | regucalcin | 2,5 |
| SGPP1 | sphingosine-1-phosphate phosphatase 1 | 2 |
| NR1D2 | nuclear receptor subfamily 1, group D, member 2 | 2 |
| GHR | Growth hormone receptor | 2 |
| CYP2E1 | cytochrome P450, family 2, subfamily e, polypeptide 1 | 2 |
| C4BPB | complement component 4 binding protein, beta | 2 |
| C6 | complement component 6 | 2 |
| FAAH | fatty acid amide hydrolase | 2 |
| NR0B2 | nuclear receptor subfamily 0, group B, member 2 | 2 |
| PCSK9 | proprotein convertase subtilisin/kexin type 9 | 2 |
| UNG | uracil-DNA glycosylase | 2 |
| CEBPA | CCAAT/enhancer binding protein (C/EBP), alpha | 5 |
| PCAF | p300/CBP-associated factor | 5 |
| CFB | complement factor B | 5 |
| DBP | D site albumin promoter binding protein | 5 |
| ADRA1B | adrenergic receptor, alpha 1b | 5 |
| FABP1 | fatty acid binding protein 1, liver | 5 |
| VIPR1 | vasoactive intestinal peptide receptor 1 | 5 |
| ID4 | Inhibitor of DNA binding 4 | 5 |
| NOX4 | NADPH oxidase 4 | 5 |
| AMY1 | amylase 1, salivary | 6 |
| GPLD1 | glycosylphosphatidylinositol specific phospholipase D1 | 6 |
| SMOC1 | SPARC-related modular calcium binding protein 1 | 6 |
NOTE: The numbers from 1–6 indicate GO terms: angiogenesis, apoptosis, cell adhesion, cell migration, cell proliferation and extracellular matrix, respectively.